Restylane is more granular, while Juvéderm is softer. For this reason, Juvéderm is often used to treat finer lines and wrinkles in narrower areas of the face, such as smile lines. Restylane, which stays better in place when injected, may be more adept at adding volume to sunken areas of the face. The biggest difference between Restylane and Juvederm is their texture.
Restylane is granular and more cohesive, while Juvederm has a softer texture. These differences in texture give both fillers different strengths. Juvederm's smoothness makes it better address fine lines and wrinkles in tight facial areas. In contrast, Restylane's cohesive nature allows it to stay in place in the injectate, making it ideal for adding volume to specific sunken facial areas.
Restylane is also moldable, allowing the injector to better create shapes and contours. Restylane and Juvederm are excellent lines of hyaluronic acid filler products that treat similar areas of the face. Restylane is manufactured by the pharmaceutical company Galderma, while Juvederm is from Allergan, the makers of Botox. A key difference between Restylane and Juvederm has to do with the consistency of the injectable.
The Juvederm formulation has a soft gel-like consistency, whereas Restylane is comprised of a granular or particulate gel. Because of this, Juvederm diffuses rapidly into the tissue and Restylane tends to be more cohesive and stay where it is initially injected. The most notable difference between the two injectable fillers is in texture. Juvederm has a softer texture than Restylane, making it a better choice for reducing fine lines and wrinkles, especially in the eye area.
Juvederm is known as a “smooth dermal filler”. Unlike Restylane, it doesn't stay in one place or leave bumps. Instead, it spreads and moves after the injection. This makes Juvederm ideal for smoothing fine lines and wrinkles, but less suitable for filling in sunken or hollow areas.
Juvederm Ultra Plus XC, Juvederm Vollure XC and Juvederm Volbella are also used to soften the vertical lines of the lips and add natural volume to the lips.